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A new study at Duke, revealed in Nature, https://stemcellprocedurescanada.com/ finds that mesenchymal stem cells (MSCs) provided the same stage of benefit as injected corticosteroids to patients with knee osteoarthritis (OA). Conducted at four sites with 480 numerous members with varying ranges of OA severity, the Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES) study in contrast outcomes from MSCs derived from autologous bone marrow aspirate concentrate, autologous stromal vascular fraction, and allogenic human umbilical cord tissue to the gold-normal corticosteroid injection.

Prior survey-based studies discovered strong indications of benefit from MSC remedies for OA. However, the one-blinded, randomized managed MILES research showed an equal stage of enchancment after a yr for all three MSC conditions and the corticosteroid injection.

"Physicians can assist to create the circumstances, but it’s our personal our bodies that do the work of healing," says Blake Boggess, DO, principal investigator for the Duke site of the research. "We were hoping that using stem cells would help in that course of, but we had been stunned to search out that no possibility was higher than the opposite."

To refer a patient, call Duke's Consultation and Referral Center at 800-633-3853 or log into Duke MedLink.

Assessing MSCs for OA

Patients were randomly assigned to one of the three MSC circumstances or to the corticosteroid injection. The results were assessed in multiple methods, together with a self-reported pain rating, questionnaire and imaging assessments.

Although a lot of prior studies have found corticosteroid injections to profit for less than three months, the MILES examine patients that received corticosteroid injections had decreased pain up to one 12 months. Patients receiving MSCs confirmed the same benefit with pain scores that additionally improved throughout the board. Independent radiologists decided that a yr after receiving the remedy some patients’ knees confirmed improvement on the MRI. These modifications can be further investigated in subsequent papers with an extension study that can additional characterize MRI changes two and three years after treatment.

The study confirmed that MSCs are a safe treatment with no adversarial reactions observed, but MSCs should not the "fountain of youth" they are sometimes portrayed as. "People are available in with excessive hopes based mostly on stem cell centers’ promoting," Boggess says. "I’ve had patients who’ve been to stem cell centers the place they ‘guaranteed’ the patient would by no means need a knee replacement, and that’s not the case.